CD11b hyperactivation improves response to immunotherapy in pancreatic cancer
نویسندگان
چکیده
منابع مشابه
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.
Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor microenvironment. Critical drivers of immune escape in the tumor microenvironment include tumor-associated macrophages and myeloid-derived suppressor cells, which not only mediate immune suppression, but also promote metastatic dissemination and imp...
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ژورنال
عنوان ژورنال: HPB
سال: 2018
ISSN: 1365-182X
DOI: 10.1016/j.hpb.2018.06.1957